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Home  >  Viagra

Viagra :

Brand Name:
Viagra® Active Ingredient: sildenafil citrate Strength(s): 25mg, 50mg & 100mg Dosage Form(s): Oral tablet Company Name: Pfizer Inc. Availability: Prescription only *Date Approved by FDA: March 27, 1998 *Approval by FDA does not mean that the drug is available for consumers at this time.

Viagra is used to treat impotence in men. Viagra increases the body’s ability to achieve and maintain an erection during sexual stimulation. Viagra does not protect you from getting sexually Men who are currently using medicines that contain nitrates, such as nitroglycerin should not use Viagra because taken together they can lower the blood pressure too much.

Viagra should not be used by women or children. In clinical studies, Viagra was assessed for its effect on the ability of men with erectile dysfunction (ED) to engage in sexual activity and in many cases specifically on the ability to achieve and maintain an erection sufficient for satisfactory sexual activity.

VIAGRA was evaluated primarily at doses of 25 mg, 50 mg and 100 mg in 21 randomized, double-blind, placebo-controlled trials of up to 6 months in duration, using a variety of study designs (fixed dose, titration, parallel, crossover).

VIAGRA was administered to more than 3,000 patients aged 19 to 87 years, with ED of various etiologies (organic, psychogenic, mixed) with a mean duration of 5 years. VIAGRA demonstrated statistically significant improvement compared to placebo in all 21 studies.

In eight double-blind, placebo-controlled crossover studies of patients with either organic or psychogenic erectile dysfunction, sexual stimulation resulted in improved erections, as assessed by penile plethysmography, after VIAGRA administration compared with placebo.

Most studies assessed the efficacy of VIAGRA approximately 60 minutes post dose. The erectile response, as assessed by penile plethysmography, generally increased with increasing sildenafil dose and plasma concentration. The time course of effect was examined in one study, showing an effect for up to 4 hours but the response was diminished compared to 2 hours.

Single oral doses of sildenafil up to 100 mg produced no clinically relevant changes in the ECGs of normal male volunteers. Single oral doses of sildenafil (100 mg) produced an average decrease of about 10 mmHg in normals, similar to the effect in patients with ischemic heart disease given 40 mg of sildenafil I.V.

Larger but similarly transient effect on blood pressure were recorded among patients receiving concomitant nitrates (see CONTRAINDICATIONS). These effects are possibly related to PDE5 in vascular smooth muscle.

A comprehensive battery of visual function tests was conducted at doses up to twice the maximum recommended dose. Mild, transient, dose-related impairment of color discrimination (blue/green) was detected using the Farnsworth-Munsell 100-hue test, with peak effects near the time of peak plasma levels.

This finding is consistent with the inhibition of PDE6, which is involved in phototransduction in the retina. In flexible titration studies of 4 to 26 weeks, 3% of patients on sildenafil reported visual disturbances, described as color tinge or light sensitivity, compared to no such findings in placebo-treated patients.

Viagra was not studied in patients who have a history of the following conditions: Heart attack, stroke, or life-threatening irregular heart rhythm within the last 6 months Very low and very high blood pressure, Heart failure or unstable chest pain.

Certain eye disorders because Viagra lowers blood pressure, your doctor will evaluate your overall medical condition to determine if Viagra, in combination with sexual activity, could adversely affect you.

Viagra can cause a rare but serious condition of prolonged erection (priapism). It is important to contact your health care provider immediately if your erection lasts longer than 4 hours. Men for whom sexual activity is inadvisable may not be good candidates for Viagra. Tell your doctor if you are taking protease inhibitors for the treatment of HIV.












   
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Viagra® Active Ingredient: sildenafil citrate Strength(s): 25mg, 50mg & 100mg
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